Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona
palustris Blume Leaves on Male Hamsters
In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has
been used for various health condition. This study aims to determine the effectiveness of 70% ethanol
extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves
were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4
hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive
control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose
variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group
were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol,
LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70%
ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total
cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract
with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood
triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to
decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded
that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in
hyperlipidemic hamster equivalent to positive control group.
http://repository.uhamka.ac.id/751/1/MICH-PhD_2018_11.pdf
