Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats
Low-Intensity Exercise Improves Neuroplasticity and
Spatial Memory on Young Adult of Male Wistar Rats
Kartinah NT, Faizah A, Ayu AD, Tahyatu B. Low-Intensity Exercise
Improves Neuroplasticity and Spatial Memory on Young Adult of
Male Wistar Rats. JEPonline 2018;21(5):19-28. The purpose of this
study was to examine the effect of low-intensity exercise on
neuroplasticity and memory performance in young Wistar adult rats.
Neuroplasticity was determined by altering the expression of
proteins such as synaptophysin, neuroligin-1, AMPAR, NMDAR, and
PSD-95 in the rat hippocampus. Six-month-old rats were randomly
divided into Sedentary (Sed) and Exercise (Ex) Groups. Exercise
rats had better spatial memory compared to sedentary rats. This
result was shown by a reduction in both the time travelled and the
total error in the Water-E Maze task (P<0.05). Immunohistochemistry
staining showed that exercise rats had higher optical density scores
of both pre- and postsynaptic proteins compared to sedentary rats
(P<0.05). In conclusion, the findings indicate that the low-intensity
exercise improves spatial learning and memory, as shown by
increased neuroplasticity and synaptic maturation in young Wistar
adult rats.
http://repository.uhamka.ac.id/811/1/JEPonlineOCTOBER2018_Kartinah.pdf
