Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters

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Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters

http://repository.uhamka.ac.id/815/

Elly Wardani, Elly

Diabetes mellitus is a disease characterized by hyperglycemia as well as progressive changes to the
pancreatic beta cell structure. This study was conducted to determine the antihyperglycemic activity of
ceplukan herb extract (Physalis angulata L.) in alloxan-induced male Syrian hamsters and high cholesterol
feed. The study used 24 hamsters divided into six groups. Group I were given a standard diet and regular
drinking water, Group II were given metformin dose 61,66 mg/kg body weight (BW), Group III were
alloxan-induced and high cholesterol feed, Groups IV, V and VI were given extract dose 60, 120 and 240
mg/kg BW respectively. The animals were induced alloxan monohydrate as well as were given high
cholesterol feed during treatment. Blood sampling was performed on the 29th and 44th day using a clinical
spectrophotometer. The results show significant differences between treatment groups (α <0,05), followed
by Tukey test. In conclusion, the preparation of herbal extract test ceplukan at doses of 120 and 240 mg/kg
BW could reduce blood glucose levels by 50.84% and 43.41% which is equivalent to metformin dose of
61.66 mg/kg BW with a percentage of 53.12%.

http://repository.uhamka.ac.id/815/1/MICH-PhD_2018_23.pdf

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